I think they found actual bone hurting juice.

(follow up: Anti-Bone-Hurting-Juice)

Your Bones Secrete a Stress Hormone Causing Fight-or-Flight Response

Mediation of the Acute Stress Response by the Skeleton

I like the reasoning that it might have originated out of the fact that bones are inherently a defensive structure within our bodies. if you take that idea and really run with it maybe vitamin D and its association with bone health might be interrelated for similar reasons. With vitamin D being an anti-inflammatory having to do with the sun.

Part of the reason why I've been tracking down certain hormones and interaction with fat cells is that I think they play a role in stress response for similar reasoning. I never stopped to think about the bones themselves. So this is actually kind of cool because they just solved the problem I was trying to track down.

My reasoning is that if our immune system is like an ant colony we ought to see local and global equivalent to stress response indicators. there's a huge difference in what pheromones ants put out depending on if you harass them vs crush them. And their response on a larger scale depends on how many are crushed and how many are around. so if these results hold out then literal bone hurting juice is the local fast-acting phenomena.

Interestingly this suggests that insects, who don't actually have bones but a carapace, may leverage a different chemical signal to have the body denote stress.

Vitamin D seems to regulate this stuff

Vitamin D metabolites regulate osteocalcin synthesis and proliferation of human bone cells in vitro.

The bone-metabolism loop has recently been expanded to include osteocalcin, which appears to play a more direct role in pancreatic beta cell function and energy metabolism. We hypothesized that both vitamin D and osteocalcin would correlate negatively with indices of adiposity-related comorbidity risk in periadolescents, varying by ethnic group.
Vitamin D, osteocalcin, and risk for adiposity as comorbidities in middle school children.

I thought this might be through cholesterol calcium mechanism but it seems it's actually downstream of it.

It's fascinating to think that some of the statins on the market are differentially affecting this process in weird ways which explains why we get different results on the impact of bone density.

All sorts of crazy shit happens at the intersection.

Association Between Bone Mineral Density, Bone Turnover Markers, and Serum Cholesterol Levels in Type 2 Diabetes

There's a fascinating theory is that it's possible all of the negative effects we see around type 2 diabetes and metabolic system might actually be the body trying to fix itself. This shows up here almost explicitly when doing a regression analysis.

Independent Relationship of Osteocalcin Circulating Levels with Obesity, Type 2 Diabetes, Hypertension, and HDL Cholesterol.

This kind of thing just falls out of the theory I have that we are able to metabolize calcium in a similar way as bears it's just that we're not because we don't have the right microbes for it.

Microbial osteoporosis: The interplay between the gut microbiota and bones via host metabolism and immunity

For me it's just a matter of getting the evidence corralled.

So theoretically all this suggests that if you go up at higher elevations you should experience some kind of fight or flight syndrome due to differentially loading your skeleton. I wonder if there's high rates of panic when air pressure changes. could this be how animals are able to detect tsunamis before humans?
it also suggests that there might be an anxiety induced form of psychosis that could occur when you climb mountains? I'm just spitballing here.


Lowering barometric pressure aggravates depression-like behavior in rats.

I wonder if that depression thing is related to this phenomena

Lowering barometric pressure induces neuronal activation in the superior vestibular nucleus in mice

So it looks like somebody already did the test and I wanted to do to see how pressure influences microbiota.

The effect of exposure to high altitude and low oxygen on intestinal microbial communities in mice

There's also some indication that honey bees can detect air pressure changes as part of how they integrate information to decide when to stop foraging and start preparing for winter.

If it is a microbiome driven process, theoretically we could measure that variation across the same bee species who share the same genes but different microbiome depending on where they live. Could even take one and introduce it to a northern climate see if it responds differently to pressure changes.

We have to control for the flowers that they eat though which might be challenging. I'll have to try the meme the people doing studies like this at Dartmouth into trying it. I know they have a sealed flower area to study how bees decide what flowers to eat.

Anyway that's my rant for today while I'm sitting outside in the sun drinking coffee.

i haven't wondered hard enough why lymphocytes come from bone marrow but I think this is an interesting connection


These results suggest that vitamin D3 is essential for the normal development of certain biological responses of lymphocytes and macrophages.

Bone Hurting Juice Tho.
ultimape ๐Ÿœ๐Ÿ’ฉ