Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut

The gut microbiota regulates levels of serotonin (5-HT) in the gut, affecting the mammalian nervous system. But does 5-HT affect the microbiota? Here, it is shown to increase the relative abundance of spore-forming members of the gut microbiota and enhance mouse colonization by Turicibacter sanguinis, a gut bacterium that can take up 5-HT and modulate systemic lipid homeostasis.