> https://www.sciencedaily.com/releases/2018/03/180312201647.htm what do you think about this
I've been exploring t-cell issues lately - seems to be related to crohn's disease and possibly other issues in my family.
Something weird I found in my research is that most people with autism have higher rates of cancer causing genes, but oddly lower rates of cancer. Its one of a number of features that make me think it's a side effect of immune regulation issues that perhaps also effect brain growth.
The social defects in autism are nuanced. I suspect there is more than one involved but get grouped together under the condition.
that study... just got interesting really fast http://www.pnas.org/content/97/22/12272.short https://academic.oup.com/ijnp/article/15/9/1307/671287
> I wonder if that's why I get more social when I smoke a lot of pot; totes has an immune suppression effect
CBD stimulates serotonin directly and also acts as a mild ssri
I have a very strong response to having a fever. feel a lot more lucid and under control of my anxiety.
Something about heat shock protiens. I wonder if they trigger stuff with the t-cells down the line.
places that swear by suanas tend to have higher rates of autism and genetically simlar conditions. lots of native americans have higher rates of autism associated genes and they had sweat lodges. I don't think that's a mistake.
Link between brown adipose and suanas is old: https://www.ncbi.nlm.nih.gov/pubmed/2736003 but... white adipose tissue seems to be part of the immune system response curiously enough: https://www.youtube.com/watch?v=4at3bqjqvsU
There's some fancy infrared stuff I found that might do the same thing, but they're all super expensive and full of new-age hokum branding. I think I can make my own though. the fancy one I found seems to pulse it and basically just have LED rods hooked up to a puck and a sinewave generator. Hard part is finding the right LED frequency, I think different wavelenghts penetrate stuff at different levels.
lol "Heat shock proteins induce T cell regulation of chronic inflammation" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1798372/
so that cancer drug effects t-cells, indirectly helps autism. The amygdala/rgs2 gene also modulate the immune system and directly affects T-cells. They don't know how, but it seems to regulate serotonin.
>Our findings demonstrate a relationship between Rgs2 gene expression level and a propensity for anxious and depressive-like behaviour and reduced social interaction that may involve changes in serotonergic receptor expression.
So study on that guesses it's because it modulates the serotonin gene expression.... But what if it actually regulates the gut microbiome thus changing the ammount of serotonin being created? So my hypothesis is that Romidepsin is undoing the high immune system response from amygldala related mutation and expression.
This is beautiful, I now have the way that the amygdala communicates back with the gut.
gut microbes -> serotonin -> vagus nerve -> amygdala -> immune response -> regulate gut microbes
its why fevers make me feel better?
its a feedback loop too which suggests it can get stuck in a bad state or "explode"
I mean, of course the t-cells are going to be involved in the cess-pit of bacertia in your gut. How else is the body going to keep them in line? https://www.sciencedaily.com/releases/2017/10/171023123802.htm
And so yeah.
https://en.wikipedia.org/wiki/Selective_serotonin_reuptake_inhibitor#Anti-inflammatory_effects
I'm going to be money that weening off breastmilk triggers an immune system cascade in infants. Most people in modern times ween their kid at the same time as they give them vaccines and I think thats why so many people associate them with autism symptoms expressing themselves.
in infants the immune system doesn't kick in until after they are done breast feeding - its so that the colostrum from the milk gets a chance to get the microbiome to populate itself. in c-section births that microbiome isn't there inside of the baby because they dont' go thru the vagina and 'eat' it. Their mother's milk provides all the t-cells they need. When they ween, their own t-cell system kickstarts itself. If there are irregularities in that system, it could cause issues too.
in most cases of autism, their microbiome isn't very varied - if their immune system is in overdrive it could be one of a couple of causal factors contributing to that.
Which... is what i'm trying to fix.
He said that while it may be possible that SSRI drugs may restore a healthy immune function in people who are depressed and prone to infections, it is possible that they might also bolster immunity to the point that they trigger autoimmune disease.
>
>The surprising finding that serotonin is rapidly passed between immune cells in a manner similar to its transmission between brain neurons was revealed in mid-October, when the research team published the findings in the journal Blood. In December, the discovery was highlighted for the general scientific audience by the journal Nature Reviews Immunology, and now the research team is working to produce an animal model that may help describe the precise nature of this interaction.
>
>"The novelty is that we reveal a potential communication, involving the transmitter serotonin, between immune cells that is normally only found between neurons," Ahern said.
https://www.sciencedaily.com/releases/2006/01/060119230939.htm
We're just walking beehives - w/ neurons acting as stationary bees. These beehives signal by frowning at each other. Same diff.
https://twitter.com/ultimape/status/750521849453350914
Speed accuracy trade off you say? A swarm of stationary bees buzzing the vote in just under the timer. Aha! moment.
http://www.sciencedirect.com/science/article/pii/S0960982217307844
No really, our minds are perhaps best modeled as networks of stationary swarm in a slowly evolving network: https://twitter.com/ultimape/status/721357716686372864
Fits with idea of modeling brain as swarms. Bee/Ant Range voting synonymous with spiking neurons: https://twitter.com/ultimape/status/716083710462976001
"some scientists now think our brains might actually work in the same way"
https://www.youtube.com/watch?v=q-5XjWZlosg
Analogy: Sickel Cell is a disease that is really only a bad things if you have two copies of a mutation. If you only have 1 copy, you are still resistant to malaria. So it persists.
Brain development patterns might be exhibiting similar high-risk/high-reward knife-edge forces.
Throw in the Hygiene Hypothesis along with microbiome's effect on stuff involving cholesterol processing (the brain is 25% cholesterol...), and the mood
regulating effects of the gut-brain axis, and viola... well, lets just say there's probably a reason why western countries are seeing IQ associated genes in decline.
A very selective gut that is trying to prefer high IQ associated microbes would lead to a similar risk/reward trade off. That is the current high-level hypothesis i'm operating under among a couple.
