Reading about DMT trips to explore a hunch that I am making DMT in my brain when my serotonin production systems are asleep.

"During a trip like that, you don't feel any fearβ€”all you experience is an indescribable sense of connection and love. But when I came back to reality, I shit my pants. It was traumatizingβ€”yet at the same time, it was beautiful."

All I can think is "i wonder if thats because of DMT's impact on gut motility, and perhas why not sleeping for a long time fixes my constipation"


"Its purgative properties are important (known as la purga or "the purge"). The intense vomiting and occasional diarrhea it induces can clear the body of worms and other tropical parasites,[30] and harmala alkaloids themselves have been shown to be anthelmintic.[31] Thus, this action is twofold; a direct action on the parasites by these harmala alkaloids (particularly harmine in ayahuasca) works to kill the parasites, and parasites are expelled through the increased intestinal motility caused by these alkaloids."

Biosynthesis of DMT from tryptamine requires double methylation reactions catalyzed by indolethylamine-N-methyltransferase (INMT)15,16. INMT mRNA was identified at high levels in peripheral tissues in rabbits17 and in humans18. However, this peripheral INMT also methylates other ligands such as histamine17,19. In the brain, INMT mRNA was found at very low levels in rabbits17 and was undetectable in humans18. No study to date has yet identified INMT in the cerebral cortex in any species. In addition to INMT, production of DMT requires aromatic-L-amino acid decarboxylase (AADC), which removes the carboxyl group from dietary tryptophan to form tryptamine, the essential DMT precursor that can be rapidly metabolized by monoamine oxidase20."

"Our discovery of tryptophan decarboxylases in the intestinal microbiota raises the possibility that microbes can sequester tryptophan from the diet, convert it to tryptamine, and thereby alter the spectrum and distribution of tryptophan metabolites that result in the host. Reducing the level of plasma tryptophan would decrease the production of serotonin in the brain, and could represent one mechanism by which the microbiota influence behavior."